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Their discovery fuels the work of researchers who study the development of embryos, the genesis of diseases or the workings of cells. The technique is used to disable or weaken single genes, illuminating their roles in disease and aging, and has produced more than 500 mouse models of human disorders such as hypertension and cystic fibrosis, which may aid drug studies.
``This is staggering,'' Capecchi, 70, said in an interview. He called the 3 a.m. phone call from Sweden ``a huge surprise.''
Capecchi was born in Italy, where he was forced to wander the streets for four years after his mother was imprisoned by the Nazis in a concentration camp. His mother found him after World War II and brought him to live with his aunt and uncle in the U.S. He completed his thesis work under James D. Watson, who won the Nobel Prize in Medicine along with Francis Crick in 1962 for their work on the structure of DNA.
Now a human geneticist at the University of Utah in Salt Lake City, Capecchi and Smithies, 82, of the University of North Carolina at Chapel Hill, showed how a mouse's genetic information can be permanently changed, creating animals that pass down their disease traits to their offspring.
Early in 1963 The Drifters (produced by Leiber-Stoller since 1959) recorded a Mann/Weil composition called "Only In America." When Atlantic decided not to release it the vocals were erased and replaced by Jay and the Americans. "Only In America" was released in July, 1963 and became their first chart hit (#25) with Jay Black singing lead. Leiber and Stoller's work with the Drifters and the Coasters caused them to turn over production of the group's material over to Artie Ripp of Kama Sutra Productions (Later to be Kama Sutra Records). One year and two singles later they had their biggest hit with "Come a Little Bit Closer" (#3). "Let's Lock the Door (#11) and "Think of the Good Times" both charted in the summer of 1965. At this time they began the second phase of their career with "Cara Mia" (#4). Beginning with Cara Mia" the group began covering successful oldies. Their next release was "Some Enchanted Evening" (#13) followed by Neil Diamond's first songwriting success "Sunday and Me" (#18).
Even the imprisonment of lobbyist Jack Abramoff and former Rep. Duke Cunningham, R-Calif., on corruption charges that included earmark abuses has not dulled lawmakers' appetite for pet projects. One recent study found that earmarks in House legislation went from 3,000 in 1996 to 15,000 in 2005.
And Obey said earlier this year that House members had requested 32,000 earmarks in spending bills for fiscal 2007.